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KMID : 1120320190050040128
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Osteoporosis and Sarcopenia
2019 Volume.5 No. 4 p.128 ~ p.131
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Efficacy of zoledronic acid in older prostate cancer patients undergoing androgen deprivation therapy
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Kojima Ippei
Naito Yushi
Yamamoto Akiyuki
Terashima Yasuhiro
Sho Norie
Nagayama Jun
Okada Yurika
Nagai Tatsuya
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Abstract
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Objectives: The purpose of this study is to evaluate the efficacy of annual zoledronic acid treatment in Japanese patients with nonmetastatic prostate cancer during androgen deprivation therapy (ADT).
Methods: This is a single institution 12-month study. Between 2016 and 2019, patients aged 70 years or older on ADT for nonmetastatic prostate cancer had bone mineral density (BMD) measured and 10-year probability of fracture calculated using fracture risk assessment tool (FRAX). Patients who showed osteopenia or had a 10-year hip fracture risk ≥ 3% or a 10-year probability of major osteoporotic fracture ≥ 20% were offered treatment with zoledronic acid 5 mg intravenously (ZA group). The patients who did not receive treatment were set as the control group. Lumbar and hip BMD were measured 6 and 12 months after treatment in the ZA group and 12 months after baseline in the control group. The yearly BMD change of both groups was compared.
Results: The mean ages of the ZA group (n = 26) and control group (n = 12) were 80.5 ± 9.1 and 76.1 ± 6.7 years, respectively. In the ZA group, lumbar and hip BMD changes at 12 months were +2.1% and +0.8%, respectively. In the control group, lumbar and hip BMD changes were ?0.9% and ?4.9%, respectively. There were statistically significant differences between the 2 groups in BMD percent changes (P < 0.05).
Conclusions: Without intervention, BMD tends to continue to decrease during ADT. Our findings suggest that administration of zoledronic acid enables maintenance of BMD in the older adults.
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KEYWORD
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Androgen deprivation therapy, Bone mineral density, Osteoporosis, Prostate cancer, Zoledronic acid
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